are glycerin suppositories safe for kidney disease

Similar to other laxatives, bulk-forming laxatives can cause gastrointestinal side effects like bloating, diarrhea, and nausea. A Guide to Chronic Pancreatitis Treatment, Acute Pancreatitis Treatment: What You Need to Know. Peripherally Acting mu-Opioid Antagonists. For potential or actual medical emergencies, immediately call 911 or your local emergency service. Read all information given to you. Check with your Uses Warnings Before taking Side effects Interactions Dosage 3. Constipation in children and young people: Diagnosis and management. Purohit TJ, et al. What is the life expectancy for a patient with stage 4 kidney failure? Stimulant laxatives are usually recommended when osmotic laxatives don't work. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. One product may be preferred depending on whats causing your constipation. ConstipationSelf care. Well also review the different. Are glycerin suppositories safer than senna laxatives? Laxatives are typically used for constipation management; however, little is known about laxative use and its associated Do not share your drugs with others and do not take anyone else's drugs. Chronic constipation occurs in 16% of adults, with older patients experiencing constipation more often.1 About one-third of adults 60 years or older report at least occasional constipation1, and in nursing home residents, the prevalence is 50% or more.2 Approximately 33 million adults in the United States have constipation resulting in 2.5 million physician visits and 92,000 hospitalizations each year.3. WebThese medications are used to treat acid reflux and heartburn, and some studies suggest that they can increase the risk for kidney disease, osteoporosis, or other nutritional Studies with patients up to 86 years of age showed increased frequency of bowel movements and decreased abdominal pain. Osmotic laxatives are available as OTC products, including: Miralax Polyethylene glycol, or PEG (Miralax), Glycerin (Fleet and Pedia-Lax suppositories). Using a liquid glycerin suppository is a good option for it to act quickly. Such methods may be especially helpful for young children and older adults who cannot take medications by mouth, according to a 2021 review. Paediatrics Child Health. Healthline Media does not provide medical advice, diagnosis, or treatment. You should stay on your side for 1520 minutes. Lie on your side and raise your knee to your chest. How long after using a suppository can I poop? A systematic review of laxative treatment in older persons showed varying degrees of effectiveness and concluded that therapy should be individualized.16 There are limited data on long-term use of medications for constipation in older persons. what signs you had. Video chat with a U.S. board-certified doctor 24/7 in a minute. Medication from a rectal suppository tends to work quickly. Saline laxatives usually work within 30 minutes to 6 hours. Are glycerin suppositories safe? An RCT of 30 men 65 to 86 years of age showed that sorbitol and lactulose were equally effective in treating constipation.19 Another RCT of nursing home residents with an average age of 85 years found that lactulose was more effective than placebo.28 Lactulose may cause diarrhea in patients who are lactose intolerant. Glycerin a rectal suppository usually takes 15 minutes to 1 hour to work. Its always best to talk to your healthcare provider or pharmacist about which constipation medication is best for you. If youre still experiencing constipation after 7 days, contact your healthcare provider. Please enable it to take advantage of the complete set of features! Which drugs or supplements interact with glycerin suppository? This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. Stool softeners usually have minimal side effects. Pedia-Lax Warnings Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, stomach pain, nausea, or vomiting. (2020). A previous article in American Family Physician reviewed the diagnostic approach to chronic constipation in older adults (https://www.aafp.org/afp/2011/0801/p299.html). Siegel, J. D., et al. Rectal suppositories are used for administering medications when you cannot do so orally. Research shows that as many as 15% of people in the world are affected by chronic constipation. According to a 2019 review of research, certain health conditions that affect the gastrointestinal (GI) tract may also reduce the effectiveness of the drugs being administered rectally, and even increase the risk of pain. Clinics in Colon and Rectal Surgery. They may monitor your electrolyte levels or recommend another laxative. senna suppositories in 30 minutes, but may not occur for some individuals for up to 2 hours. Rectal suppositories are alternatives to taking oral medications. WebSafe and effective use of glycerin rectal suppositories is not established for children under 2 years of age. If the first position is not comfortable, or if youre having difficulties inserting the suppository, you can also try kneeling face down with your hips lifted, and your head toward the floor. Long-term use of magnesium-based laxatives should be avoided because of potential toxicity. Written by Cerner Multum. Never disregard or delay professional medical advice in person because of anything on HealthTap. If you have any of these health problems: Bowel block, belly pain. It draws water into the intestines. All rights reserved. Clinicians should discuss goals of treatment with patients and caregivers. It is probably safe to use, but if you use it for more than a few days in a row, you, the risk of dehydrating yourself, which is bad in, . (2021). any drug without checking with your doctor. Trademarks, brands, logos, and copyrights are the property of their respective owners. (2018). Stimulant Suppositories and Enemas. Glycerin is a hyperosmotic laxative. Clinical Trials and Safety: Your Questions Answered. stream After inserting the suppository, you should wait 1520 minutes for the suppository to melt and stimulate a bowel movement. Before Use this medicine (glycerin suppositories) as ordered by your doctor. Polyethylene glycol (Miralax) is preferred over lactulose for the treatment of constipation because it is more effective and has fewer adverse effects. Because the suppository is already in liquid form, there is no need to wait for it to dissolve. This helps avoid straining during a bowel movement, which is especially important in people with heart conditions or hemorrhoids. Wash your hands right away with soap and warm water. Alimentary Pharmacology & Therapeutics. <> Intake should be slowly increased over several weeks to decrease adverse effects, including flatulence, abdominal cramping, and bloating.13. To remove feces from the body to prevent contamination during surgery. However, many people have no side effects or only have minor side effects. Its available under the brand names Senna-S, Dok Plus, or Senexon-S. It is not a substitute for professional medical advice, diagnosis or treatment. You can poop immediately after using a suppository. Laxative Use and Change in Estimated Glomerular Filtration Rate in Patients With Advanced Chronic Kidney Disease. 2021 Oct 27:10.1111/sdi.13030. Learn more about her work at her website. Glycerin suppositories side effects How to safely give acetaminophen. But some fleet enemas (sodium bisphosphate) containing Wet suppository before putting in rectum. But, if this isnt enough, there are many different OTC treatment options for constipation. These steps should make it easier to insert a rectal suppository. Side effects Osmotic laxatives usually have minimal side effects, but the most common level of phosphates to a non desirable level. To make sure glycerin rectal is safe for you, tell your doctor if you have: nausea, vomiting, or stomach pain; rectal bleeding; a change in bowel habits that has Osmotic laxatives allow water to be easily absorbed in the small intestine. It stimulates the muscles around the rectum and makes them contract to expel the stools. 2021 Nov 3;22(1):363. doi: 10.1186/s12882-021-02572-y. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Diarrhea is the most common adverse effect and led to cessation of treatment in 4% of patients.24, Probiotics. The following side effects can occur with stimulant laxatives: Saline laxatives are available as OTC products, including: Magnesium oxide (Phillips Laxative Caplets). (2005). Advertising revenue supports our not-for-profit mission. Now, youll enjoy a streamlined experience created specifically for healthcare providers. Non-medication interventions like increasing your fiber intake should be tried first. (n.d.). Follow all instructions closely. Many times this medicine (glycerin suppositories) is used on an as needed basis. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. sharing sensitive information, make sure youre on a federal This One study found that around 16% of U.S. adults experience constipation. Docusate. They have few side effects when used occasionally and as directed. From drinking plenty of water to keeping a food diary, here are 10 ways to ease your daily discomfort if you're living with Crohn's. (2021). Laxative Use and Risk of Dyskalemia in Patients with Advanced CKD Transitioning to Dialysis. We address the safety of clinical trials and discuss what you should consider before deciding to participate. American College of Obstetricians and Gynecologists. Molnar MZ, Streja E, Sumida K, Soohoo M, Ravel VA, Gaipov A, Potukuchi PK, Thomas F, Rhee CM, Lu JL, Kalantar-Zadeh K, Kovesdy CP. If possible, go to the bathroom and empty your bowels. Patients report hard stool or difficulty with defecation, but have normal stool frequency.4 Slow transit constipation, caused by abnormal innervation of the bowel or visceral myopathy, leads to increased transit time of stool through the colon with infrequent defecation, bloating, and abdominal discomfort.5 Disorders of defecation can occur in any age group but are particularly common in older patients.6 Defecation may be impaired by decreased smooth muscle contraction in the rectum or the inability to relax the muscles of defecation. FOIA Phosphate enemas should be avoided in older adults because of the high risk of electrolyte disturbances, which are sometimes fatal.25 Mineral oil enemas are a safer alternative to phosphate enemas, with local adverse effects of perianal irritation or soreness. Be ready to tell or show what was This allows for easy access to the buttocks during self-administration but can also be easier for giving the suppository to someone else. Never ignore professional medical advice in seeking treatment because of something you have read on the site. Bulking agents may be soluble, such as psyllium (Metamucil), or insoluble, such as bran, methylcellulose (Citrucel), and polycarbophil (Fibercon). Constipation in older adults. Stimulant laxatives can produce a bowel movement in 6 to 12 hours if taken orally, and 15 minutes to 1 hour if given rectally. Connect with a U.S. board-certified doctor by text or video anytime, anywhere. Xing, J. H., et al. <> Wash your hands with soap and warm water. Contact your provider if youve been taking laxatives for over a week with no improvement. Remain lying down for 1520 minutes until the suppository stimulates your bowels. For example, fever-reducing medications such as acetaminophen may be administered rectally if you cannot take the oral versions due to vomiting or other issues that might otherwise prevent you from swallowing liquids or tablets. If youre giving the suppository to someone else, you may want to place them in this second position. This work is written by US Government employees and is in the public domain in the US. To treat constipation, most healthcare providers recommend adding fiber to your diet or trying a bulk-forming laxative. This can cause too much absorption of the mineral oil. Most patients are initially treated with lifestyle modifications, such as scheduled toileting after meals, increased fluid intake, and increased dietary fiber intake. Low, A. Last updated on Aug 16, 2022. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Learn when to worry about blood in the stool and when to contact a doctor if you're pooping blood. Aside from these medications, rectal suppositories have been historically used for the administration of substances including hemorrhoid treatments and laxatives. Besides treating constipation, its commonly used to prepare the bowel before a colonoscopy. WebMark Feldman MD, in Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 2021. Tell your doctor if you are pregnant or plan on getting pregnant. You may also need a clean, single-edge razor blade and lubricating jelly. Some drugs may have another patient information leaflet. Call your doctor for medical Yamada S, Tanaka S, Arase H, Hiyamuta H, Kitamura H, Tokumoto M, Mitsuiki K, Tsuruya K, Kitazono T, Nakano T. Clin Exp Nephrol. (n.d.) Laxatives during pregnancy. Stimulant laxatives are available as OTC generic and brand name products, including Bisacodyl (Dulcolax) and Senna (Senokot, Ex-Lax). Solid (red) and dotted (blue) lines represent single and combined use of laxatives, respectively. By using our website, you consent to our use of cookies. International Foundation for Gastrointestinal Disorders. It is effective and moderately well tolerated in older adults.16 A subgroup analysis of 163 patients older than 65 years found that nausea was the most common adverse effect, occurring in 18% of patients.22 In one study of patients with constipation after orthopedic surgery, lubiprostone was as effective as senna.31 Lubiprostone may be reserved for constipation that does not respond to less expensive treatment options. Lifestyle changes like adding fiber to your diet or exercising can relieve constipation. (2016). The content on Healthgrades does not provide medical advice. StatPearls. They are generally safe for use on a regular basis but, if you have renal or heart Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. (2020). Web2. You AS, Kalantar-Zadeh K, Streja E, Park C, Sim JJ, Tantisattamo E, Hsiung JT, Obi Y, Potukuchi PK, Amin AN, Nguyen DV, Kovesdy CP, Rhee CM. All rights reserved. (2015). Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. The active ingredients that are used in suppositories, bisacodyl and glycerin, are considered Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Glycerin suppositories do not usually cause side effects. One RCT found bisacodyl to be more effective than placebo for chronic constipation; however, the average age of study participants was 55 years.21 Because of the possible adverse effects of long-term use in older persons, stimulant laxatives should be used only after fiber and osmotic laxatives have been tried. Peripherally acting mu-opioid antagonists are more effective than placebo for chronic opioid-induced constipation. Using your finger, place the pointed end of the suppository at the entrance of the rectum and then gently insert it about 1 in or 2.5 cm into the opening. The Food and Drug Administration (FDA) classifies glycerin as an additive that is generally recognized as safe (GRAS). Careers. Rectal suppositories can deliver many types of medication. https://www.aafp.org/afp/2011/0801/p299.html. Among laxative users, stool softeners were the most commonly prescribed (30%), followed by hyperosmotics (20%), stimulants (10%), bulk formers (3%), chloride channel activator (<1%) and several combinations of these. Fecal impaction should be treated with mineral oil or warm water enemas. Blood in stool can have a variety of causes. Author disclosure: No relevant financial affiliations. I can find no reason that a glycerin suppository should harm someone who has kidney failure except for acute kidney failure due to massive fluid loss. Does renal impairment require a dosage reduction? Epub 2017 Jul 5. Drug class: Laxatives. Its also available under the brand names Colace, and DocQLace. That means it's a sign of something elsesomething that is causing irregular bowel movements. Clin J Am Soc Nephrol. Patient information: A handout on constipation, written by the authors of this article. This will allow time for the suppository to melt and give you better relief. It is prescribed when other pain medications have not worked or cannot be tolerated. This site needs JavaScript to work properly. doi: 10.1111/sdi.13030. Patients typically experience other symptoms such as hard stools, abdominal bloating, pain, and distention. Pre-ESRD laxative use was defined as at least two laxative prescriptions 30-days apart during the 1-year pre-ESRD period. Osmotic laxatives are not absorbable. Review article: Diagnosis, management and patient perspectives of the spectrum of constipation disorders. This will help ensure the medication is administered properly, and will also reduce the risk of pain and other side effects. Push the suppository gently and slowly, pointed end first, into the rectum (back passage). Learn how we can help 5.4k views Answered >2 years ago WebYou should not use this medicine if you have had an allergic reaction to glycerin. Be sure to follow the instructions given for proper rectal suppository insertion. This will make it difficult to have a bowel movement without using a glycerin suppository. Oral saline laxatives can cause loose and watery stools. A second screen is used to confirm positive test results. Constipation may be present with normal stool frequency, defined as at least one stool three times per week, or with daily bowel movements.1 Chronic constipation is characterized by the presence of symptoms for at least three months out of the preceding 12 months. Mineral oil makes the surface of stools slippery, which helps them pass through the body more easily. (2017). <>>> Talk to your healthcare provider or pharmacist to discuss which stool softener or laxative is best for you. (2019). The use of laxatives increased considerably as patients neared transition to ESRD, likely mirroring the increasing burden of drug-induced constipation during the ESRD transition period. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. Magnesium toxicity is a concern with long-term use of these agents; it can cause ileus and worsen constipation. Remove all of the foil wrapper from the suppository. 2022 Jun 3;19(11):6842. doi: 10.3390/ijerph19116842. National Institute of Diabetes and Digestive and Kidney Diseases. Unless the suppository is a laxative, try not to empty your bowels for 1 hour after inserting the suppository. Video chat with a U.S. board-certified doctor 24/7 in a minute. Do not use 2 doses at the same time or extra doses. Always consult a medical provider for diagnosis and treatment. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of Defense, the U.S. Army Medical Corps, or the U.S. Army at large. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. Primary constipation is also referred to as functional constipation. No drug The effect of glycerin, if any, on the rectal mucosa is unknown. If you have any questions about this medicine (glycerin suppositories), please talk Endoscopy vs. Colonoscopy: How Do They Differ? Please seek medical advice before starting, changing or terminating any medical treatment. WebMilk of Magnesia (MOM), glycerin suppositories, enemas, and a prescription called lactulose. Rhona Lewis is a freelance health writer with a background in journalism and a passion for thorough research. They help prevent straining during bowel movements. Methods: They can provide quick relief for constipation in both children and adults. Unless the suppository is a laxative, try not to empty your bowels. Consider trimming your fingernails to help prevent cuts and scratches while inserting the suppository. Physiological and pharmaceutical considerations for rectal drug formulations. You should also talk with them if you have a history of GI conditions, or if you experience any side effects, such as ongoing pain and discomfort. This method may be preferable if you or your child cannot take medications by mouth. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. 2005-2023 Healthline Media a Red Ventures Company. Bulk-forming laxatives are available as OTC products, including: Bulk-forming laxatives add soluble fiber to the stool, causing more water absorption. Proportion of laxative use within each 6-month period over 36 months pre- and, Proportion of laxative types used alone or in combination among patients with at, Factors independently associated with pre-ESRD, Factors independently associated with pre-ESRD laxative use. You can either stand with one foot up on a chair, or you can lie down on your side with your top leg slightly bent toward your stomach and your bottom leg straight. What are normal bowel movement patterns? A glycerin suppository offers relief from constipation, which is when bowel movements become infrequent or difficult. Rectal bleeding, blood in stools Laxative use and mortality in patients on haemodialysis: a prospective cohort study. It's easier to check your kidney health at home now more than ever. Generic name: Glycerin Suppositories [GLIS-er-in] Rectal drug delivery system: An overview. (2003). 2 0 obj Hypoglycemia-Related Hospitalizations and Mortality Among Patients With Diabetes Transitioning to Dialysis. Oral PEG usually works within 1 to 3 days, and oral lactulose within 1 to 2 days. This content is owned by the AAFP. Three RCTs involving older patients showed a benefit of docusate sodium (Colace) over placebo in the treatment of constipation.16. This allows the stool to move quickly through the intestines, resulting in more frequent bowel movements. Conclusion: However, continual use may lead to the loss of regular bowel function. Get surprising tips for reducing gas and relieving painful bloating. Glycerin a rectal suppository usually takes 15 minutes to 1 hour to work. The 17 Best Foods to Relieve Constipation, Everything You Should Know About a Hair Strand Drug Test, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. Glycerin suppositories do not usually cause For non-prescription products, read the label or package ingredients carefully. Unable to load your collection due to an error, Unable to load your delegates due to an error. Youll know you have inserted the suppository far enough if the tip does not immediately come out. You should not use this medicine if you have rectal bleeding. Copyright 2015 by the American Academy of Family Physicians. If you are helping a child by using an infant glycerin suppository, follow the package instructions or talk with your childs pediatrician before administering the suppository. Diet You can learn more about how we ensure our content is accurate and current by reading our. Case of PUJ stenosis Rt side,Rt moderate hydronephrosis with reduction of renal parenchymal thickness 7mm & 1.4cm stone in lower calyx of Rt kidney. Place the pointed end of the suppository at the entrance of the rectum and then use your finger to gently insert the suppository about .5 inches (in) or 1.2 centimeters (cm) into the opening. This is a decision you and your doctor will make. And glycerine is a simple lubricant for the intestin. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Talk with a doctor if youre having issues with rectal suppositories, or if other questions and concerns arise. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. WebNo &yes: Glycerin suppositories don't cause electrolyte imbalance and is safe for heart patients! Tell your Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. A hair strand drug test can be used to detect drugs used over the past 90 days. (2020). Although there is no specific information comparing use of glycerin in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. Plain warm water enemas are safe and preferable to soapsuds enemas, which may cause rectal mucosa damage.2 Glycerin suppositories are safe alternatives to enemas and have been shown to improve rectal emptying in patients with chronic constipation.26. Saline laxatives draw water into the bowel, leading to softer stool and more frequent bowel movements. This creates a heavier stool which encourages the colon to contract and eliminate the stool. (2017). U01 DK102163/DK/NIDDK NIH HHS/United States, eScholarship, California Digital Library, University of California. Do not start, stop, or change the dose of Children of age 2 to under 6: Insert one 1 g suppository rectally, or as directed by doctor. Safe and effective use of glycerin rectal suppositories is not established for children under 2 years of age. Which drugs or supplements interact with glycerin suppository? No drug interactions have been established with glycerin rectal suppositories. DailyMed. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or [email protected] so that we can provide you with the services you require through alternative means. Treating constipation with laxatives. If you have rectal bleeding or you do not have a bowel A glycerin suppository is a solid form of laxative that is inserted into the rectum to quickly relieve temporary constipation. This over-the-counter medication is easy to use for both children and adults. Dry your hands with a clean towel or a paper towel. Copyright 2023 IBM Watson Health. Learn how food triggers can make symptoms worse and ways a six food elimination diet can help. and transmitted securely. Get answers from Critical Care Specialists and top U.S. doctors, Our doctors evaluate, diagnose, prescribe, order lab tests, and recommend follow-up care. Are glycerin suppositories safer for heart patients? Tell all of your health care providers that you take this medicine (glycerin suppositories). Findings may provide novel insight into better management strategies to alleviate constipation symptoms and reduce medication requirements in patients with advanced CKD. Healthcare providers will usually recommend you start with a small dose, and slowly raise it until you have regular bowel movements. DailyMed. MedlinePlus. Put suppository into the rectum with gentle pressure, pointed end first. 3 0 obj Glycerin Suppositories are indicated for acute and temporary episodes of constipation. 1 tsp or 1 packet one to three times per day, Bloating, abdominal distension in 4% to 18%, Bloating and cramping; nausea in up to 20%, 150 to 300 mL, single dose or short-term daily dose, Increase in magnesium, causing lethargy, hypotension, respiratory depression, Minimal adverse effects of cramping and gas, 2 to 3 tbsp, single dose or short-term daily dose, Diarrhea and abdominal pain in 56% in week 1 and 5% in week 4, Weight-based subcutaneous injection, once or twice per day, Diarrhea in 16%, which led to treatment cessation in 4%. chronic kidney disease; constipation; end-stage renal disease; laxative; transition. The sphincter is the muscular opening of the rectum. All Rights Reserved. Glycerin belongs to a class of drugs known as hyperosmotic laxatives. Factors associated with laxative use during the last 1-year pre-ESRD period were identified by multivariable logistic regression. Epub 2018 Jul 20. To learn more, please visit our, Glycerine sup does not damage kidneys. Are they safe for heart patients? taken, how much, and when it happened. The FDA classifies glycerin as an additive that is generally recognized as safe (GRAS). Pre-ESRD laxative use was defined as, MeSH If you think you may have a medical emergency, immediately call your doctor or dial 911. Doctors typically provide answers within 24 hours. Mariotti J. endobj Contact Laxative Use and the Risk of Arteriovenous Fistula Maturation Failure in Patients Undergoing Hemodialysis: A Multi-Center Cohort Study. I have a history of renal impairment + pelvocaliectasis since over a year and when im about to have my period, my kidney hurts more. To take advantage of the gastrocolic reflex, patients should schedule toileting after meals.4 They should place their feet on a small step stool instead of on the floor to straighten the anorectal junction.

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